Beyond Weight Loss: The Heartening New Benefits of GLP-1s

By Dr Mark Larkin, PhD, Director, Pharmacy Price Hound

New research presented at the European Society of Cardiology Congress last week has revealed a groundbreaking benefit of GLP-1 medications like semaglutide (found in Ozempic and Wegovy), moving the conversation far beyond just weight loss.

The landmark SELECT trial delivered practice-changing news. It involved over 17,000 adults with pre-existing heart disease who were overweight but did not have diabetes. The results were striking: semaglutide reduced the risk of major cardiovascular events—such as heart attack, stroke, and cardiovascular death—by a significant 20%.

This isn’t just about numbers on the scales. While weight loss improves heart health, this trial suggests GLP-1s offer direct protection to the heart and blood vessels, potentially by reducing inflammation.

What This Means for You

For the UK, where heart disease remains a leading health concern, this is major news. It positions GLP-1 medications as a potential new tool for cardiovascular prevention, alongside statins and blood pressure medicines.

However, a note of cautious optimism is key.

• NHS Access: Current access to these drugs for weight loss is very limited within specialist NHS services. Their use specifically for heart disease prevention is not yet standard and awaits updated medical guidelines.
• Not a Magic Bullet: These medications are a powerful tool but do not replace the proven benefits of a balanced diet, regular exercise, and not smoking.
• Speak to Your GP: If you have a history of heart disease and weight concerns, this is a development to discuss with your doctor. They can advise on your individual risk and whether this new evidence is relevant for you.

This exciting development shifts the narrative around GLP-1s from weight control to broader medical benefits, highlighting their potential to contribute to a longer, healthier life.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of your GP or other qualified health provider with any questions you may have regarding a medical condition.*